The originating document has been archived. We cannot confirm the completeness, accuracy and currency of the content. Amethia - Tablets Phase 1: levonorgestrel 0. Phase 2: ethinyl estradiol 10 mcg.
Progestin-Only Oral Contraceptives: MedlinePlus Drug Information
Interactions with oral contraceptives OCs occur with drugs commonly used to treat epilepsy, tuberculosis, and depression. Most women are more likely to use antibiotics, analgesics, and antihistamines, which have also been shown to interact with OCs. The mechanisms behind these interactions may be hepatic microsomal enzyme induction or inhibition, interference with the enterohepatic circulation of steroid metabolites, interference with absorption, competition between two drugs for the same metabolizing enzyme, or induction of an opposite physiologic effect. Rifampin was the first drug reported to interfere with the efficacy of OCs. The anticonvulsants and certain antibiotics, namely ampicillin and tetracycline, also decrease the efficacy of OCs.
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Read terms. This document reflects emerging clinical and scientific advances as of the date issued and is subject to change. The information should not be construed as dictating an exclusive course of treatment or procedure to be followed. Food and Drug Administration considers generic and brand name oral contraceptive OC products clinically equivalent and interchangeable. The American College of Obstetricians and Gynecologists supports patient or clinician requests for branded OCs or continuation of the same generic or branded OCs if the request is based on clinical experience or concerns regarding packaging or compliance, or if the branded product is considered a better choice for that individual patient.
Methods: We searched PubMed and Cochrane libraries for clinical or pharmacokinetic PK studies that examined co-administration of any HC with psychotropic drugs [selective serotonin reuptake inhibitors SSRIs , serotonin-norepinephrine reuptake inhibitors SNRIs , tricyclic antidepressants TCAs , oral benzodiazepines, bupropion, mirtazapine, trazadone, buspirone, hydroxyzine, monoamine oxidase inhibitors MAOIs , or atypical antipsychotics] in reproductive aged women. Results: Of articles identified, 22 articles 18 studies met inclusion criteria. Overall, clinical studies did not demonstrate differences in unintended pregnancy rates when HCs were administered with and without psychotropic drugs or in psychotropic drug treatment outcomes when psychotropic drugs were administered with and without HCs.